Aims and Scope

The Open Bioactive Compounds Journal is an Open Access online journal, which publishes original research articles, letters, review/mini-review articles, short articles and guest edited single topic issues on bioactive compounds.

The Open Bioactive Compounds Journal, a peer-reviewed journal, is an important and reliable source of current information on developments and research in new bioactive compounds with proven activities in various biological screenings and pharmacological models. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide, proving essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.

Editor's Choice

Insight into Erythrina Lectins: Properties, Structure and Proposed Physiological Significance

Makarim Elfadil M. Osman, Emadeldin Hassan E. Konozy

The genus Erythrina, collectively known as “coral tree”, are pantropical plants, comprising of more than 112 species. Since the early 1980s, seven of these have been found to possess hemagglutinating activity, although not yet characterized. However, around two dozen galactose-binding lectins have been isolated and fully characterized with respect to their sugar specificity, glycoconjugates agglutination, dependence of activity on metal ions, primary and secondary structures and stability. Three lectins have been fully sequenced and the crystal structures of the two proteins have been solved with and without the haptenic sugar. Lectins isolation and characterization from most of these species usually originated from the seeds, although the proteins from other vegetative tissues have also been reported. The main objective of this review is to summarize the physicochemical and biological properties of the reported purified Erythrina lectins to date. Structural comparisons, based on available lectins sequences, are also made to relate the intrinsic physical and chemical properties of these proteins. Particular attention is also given to the proposed biological significance of the lectins from the genus Erythrina.

November 14, 2017

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